Our working group concentrates on the bioinformatic analysis of next-generation sequencing (NGS) data and the establishment of the latest research methods in diagnostics. Our focus is on the analysis of DNA data, such as that generated by whole genome sequencing. To further improve diagnostics, we develop and implement new outlier detection methods and algorithms in the field of RNA sequencing. We are working closely with the German Human Genome Phenome Archive (GHGA) to establish standards for NGS analysis and build a central data resource for the German research community. Our research and the bioinformatic evaluation of NGS-based OMICs data form the basis for molecular diagnostics and the further development of personalized therapies.